Forty-year-old Sean, of Tavistock Close, will be joined by three Hucknall friends – Alan White (43), of Occupation Road, John Bradley (42), of Broomhill Park View, and Andrew Palmer (41), of Park Drive – for the gruelling coast-to-coast ride.
Between May 26 and 29 they will use pedal power to cycle from Whitehaven in the Lake District to Tynemouth in Newcastle.
Preparation has included weekly rides of between 20 and 30 miles from Bilsthorpe to Hucknall and in the Peak District.
Their aim is to raise cash for National Primary School in Montague Road, Hucknall, where seven-year-old Thomas is a pupil, and the Down's Syndrome Association.
The school and the charity have played a crucial role in helping Thomas and his mum and dad, Sean and Lisa, cope with the youngster's condition. The couple also have a two-year-old son, Dylan.
What's more, even though the quartet of cyclists have already raised £1,000 in sponsorship, they need your help to boost the coffers even further.
Anyone willing to help can call in at Hair Razors hairdresser's on Baker Street in Hucknall or Hucknall Domestic Appliances on High Street, where sponsorship forms are located.
Said Sean, who is a domestic service engineer: "My wife and I wanted to give something back to the school and the charity because they have helped us so much.
"Having a Down's Syndrome child can be hard work. Thomas has had a few health problems in the past, including bad pneumonia, but he is well at the moment.
Thomas is the first ever Down's Syndrome child to have been taught at National Primary and Sean was full of praise for the school.
"They have been great," he said. "He has his own teaching assistant and he is doing very well. Without the support of the charity and the school, it would have been more difficult for us to cope."