Drivers are being warned that a serious accident has closed part of the A611 Derby Road in Kirkby-in-Ashfield.
The road is closed in both directions at the B6139 Coxmoor Road junction.
The incident is believed to have happened in the early hours of the morning and police say the road is likely to be closed until later this morning (Friday).
A spokesman said: “As a result of a serious accident the entirety of the A611 is shut between the Shoulder of Mutton Hill and Diamond Avenue.”
“It is expected this closure could last for several hours.”