The Co-operative Food store in Selston is closed after thieves raided the store.
The criminals cut a hole in the roof to gain entry to the Nottingham Road shop sometime between 9.30pm on Wednesday and 5.45am on Thursday.
They stole with a large amount of cigarettes.
Store manager Mark Page said: "We're hoping to reopen within the next few hours."
Police are investigating the incident.
Witnesses or anyone with information should call officers on 101.