England come into the game on a high after beating Croatia in their opening game, while the Scots suffered a disappointing loss to the Czechs in their opener.
England are favourites but, as we all know in football, the formbook goes out of the window in derby games.
Here, we look back at nine famous meetings between the old enemies.
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England and Scotland meet this week in the Euros. Photos: Hugh Hastings/Jeff J Mitchell/Getty Images Photo: x
. England 1 Scotland 1, March 5, 1870
The first official meeting between the two sides took place at The Oval cricket ground in 1870 and was so nearly a famous Scottish win, but Alfred Baker snatched a last-minute equaliser for England. Photo: Other
. England 1 Scotland 5, March 31, 1928
Scotland's famous 'Wembley wizards' rang rings around England on this day with Alex Jackson netting a hat-trick and Alex James a double for the visitors, while Bob Kelly got a late consolation for England. Photo: Davis/Topical Press Agency/Getty Images
9. Scotland 2 England 2, June 10, 2018
The most recent meeting between the two was in qualifying for the last World Cup and, just like the first ever game, Scotland were seconds away from a famous win. Harry Kane rescued a draw for England. Photo: Mike Hewitt/Getty images